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Home > APIs & Organic Intermediates > Lamivudine (3TC)

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Name: Lamivudine (3TC)

Model Number: LB000000

CAS NO.: 134678-17-4
Specification: USP39/EP8.0/BP2016
Type: Anti-Aids API
Purity: 99.9%

Product Description

Packaging & Delivery
Packaging Details:25kg/drumDelivery Detail:10days


Specifications

Product Name: Lamivudine 
CAS: 134678-17-4 
Molecular Formula: C8H11N3O3S 
Molecular Weight: 229.25


1. Detail Information:

Product Name: Lamivudine 
Synonyms:  
4-AMINO-1-((2R,5S)-2-HYDROXYMETHYL-[1,3]OXATHIOLAN-5-YL)-1H-PYRIMIDIN-2-ONE

CAS: 134678-17-4

Molecular Formula: C8H11N3O3S
Molecular Weight:  229.25 
Specification: USP

2. Specification:


ASSAY ITEMS

SPECIFICATION(USP)

Appearance

White to off-white crystalline powder

Solubility

Soluble in water, sparingly soluble in ethanol, practically insoluble in ethyl acetate

Light Absorption

Not more than 0.0015 (440nm, 4cm cell, 50mg/ml)

Identification

A) The IR Spectrum of test sample corresponds to the standard IR spectrum of Lamivudine

B) The retention time of the major peak in the chromatogram of the test solution corresponds to that in chromatogram of the reference solution, as obtained in the test of Limit of Lamivudine enantiomer.

Water

Not more than 0.2%

Limit of Lamivudine Enantiomer

Not more than 0.3%

Residual Solvents

Ethanol is not more than 0.2%

Triethylamine (TEA) is not more than 0.1%

Dichloromethane is not more than 0.06%

Toluene is not more than 0.089%

N,N-Dimethylformamide is not more than 0.088%

n-Hexane is not more than 0.029%

Total residual solvents not more than 0.3%

Chromatographic Purity

Salicylic acid is not more than 0.10%

Relative retention time at about 0.4 impurity is not more than 0.3%

Relative retention time at about 0.9 impurity is not more than 0.2%

Any other individual impurity is not more than 0.1%

Total impurities

not more than 0.6%

HPLC Assay (Anhydrous basis)

Not less than 98.0% and not more than 102.0%


 3. Uses: 

Lamivudine is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).It is marketed by GlaxoSmithKline with the brand names Zeffix, Heptovir, Epivir and Epivir-HBV. Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV. It improves the seroconversion of e-antigen positive hepatitis B and also improves histology staging of the liver. Long term use of lamivudine unfortunately leads to emergence of a resistant hepatitis B virus (YMDD) mutant. Despite this, lamivudine is still used widely as it is well tolerated.


FAQ

Q1:Why do you choose Greenbo Biochem as your partner?

A1.High quality can be guaranteed. Greenbo Biochem since 1990 are reputed API manufacturer and are Certified by ISO,GMP,FDA and have CEP/COS certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C payment term. If there is any quality problem after goods arrive. Greenbo Biochem will do fully payment refund. 

A2. Best price can be guaranteed. As Greenbo Biochem are integrated pharmaceuticals and chemicals producer

the production cost can be controlled and price will be definitely more competitive than China trading companies.

A3.Professional engineer from Greenbo Biochem will give professional usage guide and services after sales.

Q2: Can i get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q3: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba).
Q4: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q5:What’s your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q6: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)










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