Name: Natamycin

Product Description

Natamycin is a natural antifungal agent that belongs to the group of polyene macrolide produced by Streptomyces natalensis. Natamycin is a crystallized substance that is colorless, odorless and tasteless. Natamycin is very stable so that it can be widely applied in the food industry for more than 30 years.

Characteristics

Ø        Nomenclature

•            International Nonproprietary Name (INN):Natamycin

•            Compendial name: Natamycin

•            Other synonym: Pimaricin

•            Molecular formula: C33H47NO13

•            Relative molecular mass: 665.73

•            Company's code: NTA

•            Chemical Abstracts Service (CAS) registry number: 7681-93-8

Ø        Physico-chemical properties

•            White to creamy-white, almost odourless, crystalline powder

•            Practically insoluble in water, lipid and mineral oils

•            Slightly soluble in methanol; soluble in glacial acetic acid

•            Non-sterile micronized or non-micronized

Ø        Biological properties

•            Natamycinis active against yeast and moulds, but not bacteria, virus, and other organisms like protozoa.

•            Natamycin isthemost effective at pH levels of between 5 and 7while the fungicide’seffectiveness may be reduced by as much as 30%at below pH 4 and above pH 9.

Compliance with Pharmacopoeia and Official Standards

Lifecome Biochemistry Co. regularly supplies both active ingredient of natamycinand formulated form of natamycin (mainly 50%) to comply with customers' needs. However, the company can supply a highly pure product of natamycin, of which contentis more than 98%.

 

Ø        Active ingredient of Natamycinconforms to US Pharmacopoeia 39

•            Content of natamycin (drybasis): 90.0%-102.0%

•            pH: 5.0-7.5

•            Water: 6.0%-9.0%

Ø        Active ingredient of Natamycinconforms to ECDirective 2008/84/EC

•            Content of natamycin (drybasis): ≥95.0%

•            pH: 5.5-7.5

•            Loss on drying: ≤ 8.0%

•            Specific rotation: +250-+295(1% w/v solution in glacial acetic acid)

•            Sulfated ash: ≤ 0.5%

•            Arsenic: ≤ 3mg/kg

•            Lead: ≤ 5mg/kg

Ø        Active ingredient of Natamycinconforms to ECDirective 2008/84/EC(Continued)

•            Mercury: ≤ 1mg/kg

•            Heavy metal (as Pb): ≤ 10mg/kg

•            Total viable count: ≤ 100cfu/g

Ø        End-Use Formulated Natamycinwith Glucose, Lactose, or Sodium Chloride

•            Content of natamycin: 50%-55%

•            pH: 5.0-7.5

•            Loss on drying: ≤ 8.0%

•            Total viable count: ≤ 100cfu/g

Indication and Application

Ø      Natamycin has been used as a natural food preservative for more than 30 years dueto its fungicidal activity against almost all fungi and yeasts. In addition, as natamycin has no antibacterial action, it does not interfere with the food’s natural maturing processes.

Ø      Natamycin can be applied on the surface of cheeses or cured meat productsby dipping the product in an aqueous solution of natamycin, or by spraying the aqueous solution around the product. The most common concentration varies between 1,000 and 2,000 ppm.

Ø    For agricultural use (bio-pesticide), natamycin is also used tocontrol dry bubble disease caused byVerticillium fungicolain mushroom production facilities.

Regulatory Compliances

Following documents and certificates are available as requested;

Ø        EU Drug Master File (DMF) with full impurity profile complies with EMA requirements

Ø        Certificates of KOSHER, HALAL, ISO9001, ISO22000, ISO14001, and OHSAS18001

Availability

Ø        Non-sterile active ingredient of natamycin(micronized/non-micronized)complieswith USP39 (purity, 90.0%-102.0%), and EC Directive 2008/84/EC (purity,≥95.0%)isavailable, respectively.

Ø        50% end-use formulations of natamycin with different excipients (Glucose, Lactose, Sodium chloride) are also available. Package sizes of the end-sue formulations are 100g×50 bottles/carton, 500g×10 bottles/carton, and 10 kg/drum, respectively.

Other Information

Ø        Self-life is 24 months from the date of manufacture

Ø        Protect contents from humidity after opening, store in a dry and cool place

Ø        Ultraviolet radiation and oxidants should be avoided

Ø        Use of natamycinis an exception to the prohibition on the use of antibiotics in the food industry, as it has no bacterial action

FAQ

Q1:Why do you choose Greenbo Biochem as your partner?

A1.High quality can be guaranteed. Greenbo Biochem since 1990 are reputed API manufacturer and are Certified by ISO,GMP,FDA and have CEP/COS certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C payment term. If there is any quality problem after goods arrive. Greenbo Biochem will do fully payment refund. 

A2. Best price can be guaranteed. As Greenbo Biochem are integrated pharmaceuticals and chemicals producer

the production cost can be controlled and price will be definitely more competitive than China trading companies.

A3.Professional engineer from Greenbo Biochem will give professional usage guide and services after sales.

Q2: Can i get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q3: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba).
Q4: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q5:What’s your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q6: How about delivery lead time?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)